setup.py

from distutils.core import setup
import py2exe, os
Mydata_files = []
for files in os.listdir('folder of assets'):
    f1 = 'folder of assets' + files
    if os.path.isfile(f1): # skip directories
        f2 = 'assets', [f1]
        Mydata_files.append(f2)
icon_location = "icon_location\\encryptor.ico"

setup_dict = dict(
    name="Application Name",
    version="1.0",
    description="description",
    author="Your Name",
    windows = [{
            "script":"script.py",
            "icon_resources": [(0, icon_location), (1, icon_location), (42, icon_location)],
            "dest_base":"exe name"
            }],
    zipfile=None,
    options={
         "py2exe": {
            "optimize": 2,
            "dll_excludes": [
            "api-ms-win-core-heap-l2-1-0.dll",
            "api-ms-win-core-delayload-l1-1-1.dll",
            "api-ms-win-core-libraryloader-l1-2-0.dll",
            "api-ms-win-security-activedirectoryclient-l1-1-0.dll",
            "api-ms-win-core-delayload-l1-1-0.dll",
            "api-ms-win-core-processthreads-l1-1-0.dll",
            "api-ms-win-core-string-obsolete-l1-1-0.dll",
            "api-ms-win-core-profile-l1-1-0.dll",
            "api-ms-win-core-errorhandling-l1-1-0.dll",
            "api-ms-win-core-sysinfo-l1-1-0.dll"
            ]

            }
        },
    data_files=Mydata_files
)

setup(**setup_dict)
setup(**setup_dict)##run it again fixes the icon bug