from guizero import App, Box, PushButton,Text

app = App()

box1 = Box(app, align="top", width="fill", border=4)
box2 = Box(app, align="bottom", width="fill", border=4)
box3 = Box(app, align="left", width="fill", border=6)
box4 = Box(app, align="right", width="fill", border=6)

message1 = Text(box1, text="This is box 1")
button1 = PushButton(box1, text="1st button")
button2 = PushButton(box1, text="2nd button")
message2 = Text(box2, text="This is box 2")
button3 = PushButton(box2, text="3rd button")
button4 = PushButton(box2, text="4th button")
message3 = Text(box3, text="This is box 3")
button5 = PushButton(box3, text="5th button")
button6 = PushButton(box3, text="6th button")
message4 = Text(box4, text="This is box 4")
button7 = PushButton(box4, text="7th button")
button8 = PushButton(box4, text="8th button")

app.display()