$ pip install -U wxPython
Collecting wxPython
  Using cached https://files.pythonhosted.org/packages/dd/31/bd55ab40e406a026a7fda0bb5eb61f466682544ae91ac26267c750f5e618/wxPython-4.0.3.tar.gz
Requirement not upgraded as not directly required: six in /usr/lib/python3.6/site-packages (from wxPython) (1.10.0)
Requirement not upgraded as not directly required: PyPubSub in /usr/lib/python3.6/site-packages (from wxPython) (4.0.0)
Installing collected packages: wxPython
  Running setup.py install for wxPython ... error
    Complete output from command /usr/bin/python3 -u -c "import setuptools, tokenize;__file__='/tmp/pip-install-48ps6e5q/wxPython/setup.py';f=getattr(tokenize, 'open', open)(__file__);code=f.read().replace('\r\n', '\n');f.close();exec(compile(code, __file__, 'exec'))" install --record /tmp/pip-record-w8jnst9m/install-record.txt --single-version-externally-managed --compile:
    running install
    running build
    WARNING: Building this way assumes that all generated files have been
    generated already.  If that is not the case then use build.py directly
    to generate the source and perform the build stage.  You can use
    --skip-build with the bdist_* or install commands to avoid this
    message and the wxWidgets and Phoenix build steps in the future.

    "/usr/bin/python3" -u build.py build
    Will build using: "/usr/bin/python3"
    3.6.6 (default, Jun 28 2018, 10:27:26)
    [GCC 7.3.0]
    Python's architecture is 64bit
    cfg.VERSION: 4.0.3

    Running command: build
    Running command: build_wx
    wxWidgets build options: ['--wxpython', '--unicode', '--gtk3']
    Configure options: ['--enable-unicode', '--with-gtk=3', '--with-opengl', '--enable-sound', '--enable-graphics_ctx', '--enable-mediactrl', '--enable-display', '--enable-geometry', '--enable-debug_flag', '--enable-optimise', '--disable-debugreport', '--enable-uiactionsim', '--enable-autoidman', '--with-sdl']
    /tmp/pip-install-48ps6e5q/wxPython/ext/wxWidgets/configure --enable-unicode --with-gtk=3 --with-opengl --enable-sound --enable-graphics_ctx --enable-mediactrl --enable-display --enable-geometry --enable-debug_flag --enable-optimise --disable-debugreport --enable-uiactionsim --enable-autoidman --with-sdl
    configure: loading site script /etc/config.site
    checking build system type... x86_64-pc-msys
    checking host system type... x86_64-pc-msys
    configure: WARNING: *** System type x86_64-pc-msys is unknown, assuming generic Unix and continuing nevertheless.
    configure: WARNING: *** Please report the build results to wx-dev@lists.wxwidgets.org.
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    checking for gcc... gcc
    checking whether the C compiler works... yes
    checking for C compiler default output file name... a.exe
    checking for suffix of executables... .exe
    checking whether we are cross compiling... no
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    checking whether we are using the GNU C compiler... yes
    checking whether gcc accepts -g... yes
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    checking how to run the C preprocessor... gcc -E
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    checking for inline... inline
    checking size of short... 2
    checking size of void *... 8
    checking size of int... 4
    checking size of long... 8
    checking size of size_t... 8
    checking size of long long... 8
    checking size of wchar_t... 2
    checking for va_copy... yes
    checking whether the compiler supports variadic macros... yes
    checking for _FILE_OFFSET_BITS value needed for large files... 64
    checking if large file support is available... yes
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    checking how to run the C++ preprocessor... g++ -E
    checking type_traits usability... yes
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    checking for pkg-config... /usr/bin/pkg-config
    checking pkg-config is at least version 0.9.0... yes
    configure: WARNING: Defaulting to the builtin regex library for Unicode build.
    checking for zlib.h >= 1.1.4... yes
    checking for zlib.h... (cached) yes
    checking for deflate in -lz... yes
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    configure: WARNING: system png library not found or too old, will use built-in instead
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    configure: WARNING: system jpeg library not found, will use built-in instead
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    configure: WARNING: system tiff library not found, will use built-in instead
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    configure: WARNING: system expat library not found, will use built-in instead
    checking for GTK+ version...
    checking for pkg-config... /usr/bin/pkg-config
    checking for GTK+ - version >= 3.0.0... Package gtk+-3.0 was not found in the pkg-config search path.
    Perhaps you should add the directory containing `gtk+-3.0.pc'
    to the PKG_CONFIG_PATH environment variable
    No package 'gtk+-3.0' found
    Package gthread-2.0 was not found in the pkg-config search path.
    Perhaps you should add the directory containing `gthread-2.0.pc'
    to the PKG_CONFIG_PATH environment variable
    No package 'gthread-2.0' found
    no
    *** Could not run GTK+ test program, checking why...
    *** The test program failed to compile or link. See the file config.log for the
    *** exact error that occured. This usually means GTK+ is incorrectly installed.
    configure: error:
    The development files for GTK+ were not found. For GTK+ 2, please
    ensure that pkg-config is in the path and that gtk+-2.0.pc is
    installed. For GTK+ 1.2 please check that gtk-config is in the path,
    and that the version is 1.2.3 or above. Also check that the
    libraries returned by 'pkg-config gtk+-2.0 --libs' or 'gtk-config
    --libs' are in the LD_LIBRARY_PATH or equivalent.

    Error running configure
    ERROR: failed building wxWidgets
    Traceback (most recent call last):
      File "build.py", line 1321, in cmd_build_wx
        wxbuild.main(wxDir(), build_options)
      File "/tmp/pip-install-48ps6e5q/wxPython/buildtools/build_wxwidgets.py", line 375, in main
        "Error running configure")
      File "/tmp/pip-install-48ps6e5q/wxPython/buildtools/build_wxwidgets.py", line 85, in exitIfError
        raise builder.BuildError(msg)
    buildtools.builder.BuildError: Error running configure
    Finished command: build_wx (0m42.819s)
    Finished command: build (0m42.819s)
    Command '"/usr/bin/python3" -u build.py build' failed with exit code 1.