SARS-CoV-2 oral vaccine booster shows promise in animal tests

The devastating medical and economic impacts of the coronavirus disease 2019 (COVID-19) pandemic have triggered an unprecedented global effort toward the development of effective vaccines to prevent infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus responsible for COVID-19.

To date, multiple vaccines have been approved in several nations around the world. Each of these vaccines is parenterally administered, which can pose various logistical challenges. Whether these vaccines offer adequate protection at the mucosal sites of entry of the virus also remains questionable.

Currently approved vaccines, as well as other vaccine candidates that are still in development, target the SARS-CoV-2 spike (S) protein, which is a surface protein that plays a key role in the entry of SARS-CoV-2 into the host cell.
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