mysql-config-1

 SELECT CEILING(Total_InnoDB_Bytes*1.6/POWER(1024,3)) RIBPS FROM
     (SELECT SUM(data_length+index_length) Total_InnoDB_Bytes
     FROM information_schema.tables WHERE engine='InnoDB') A;
+-------+
| RIBPS |
+-------+
|     8 |
+-------+
1 row in set (4.31 sec)

mysql>
With this output, you would set the following in /etc/my.cnf

[mysqld]
innodb_buffer_pool_size=8G


After the restart, run MySQL for a week or two. Then, run this query:

SELECT (PagesData*PageSize)/POWER(1024,3) DataGB FROM
(SELECT variable_value PagesData
FROM information_schema.global_status
WHERE variable_name='Innodb_buffer_pool_pages_data') A,
(SELECT variable_value PageSize
FROM information_schema.global_status
WHERE variable_name='Innodb_page_size') B;

This will give you how many actual GB of memory is in use by InnoDB Data in the InnoDB Buffer Pool at this moment.

This value DataGB more closely resembles how big the InnoDB Buffer Pool should be + (percentage specified in innodb_change_buffer_max_size). I am sure this will be far less than the 20000M you have reserved right now. The savings in RAM can be used for tuning other things like

join_buffer_size
sort_buffer_size
read_buffer_size
read_rnd_buffer_size
max_connection


SELECT CONCAT(CEILING(RIBPS/POWER(1024,pw)),SUBSTR(' KMGT',pw+1,1))
Recommended_InnoDB_Buffer_Pool_Size FROM
(
    SELECT RIBPS,FLOOR(LOG(RIBPS)/LOG(1024)) pw
    FROM
    (
        SELECT SUM(data_length+index_length)*1.1*growth RIBPS
        FROM information_schema.tables AAA,
        (SELECT 1.25 growth) BBB
        WHERE ENGINE='InnoDB'
    ) AA
) A;


===================
Something like this? Using SHOW VARIABLES and SHOW GLOBAL STATUS:

Expression: innodb_buffer_pool_size / _ram
Meaning: % of RAM used for InnoDB buffer_pool
Recommended range: 60~80%

Expression: Innodb_buffer_pool_reads / Innodb_buffer_pool_read_requests
Meaning: Read requests that had to hit disk
Recommended range: 0-2%
What to do if out of range: Increase innodb_buffer_pool_size if you have enough RAM.

Expression: Innodb_pages_read / Innodb_buffer_pool_read_requests
Meaning: Read requests that had to hit disk
Recommended range: 0-2%
What to do if out of range: Increase innodb_buffer_pool_size if you have enough RAM.

Expression: Innodb_pages_written / Innodb_buffer_pool_write_requests
Meaning: Write requests that had to hit disk
Recommended range: 0-15%
What to do if out of range: Check innodb_buffer_pool_size

Expression: Innodb_buffer_pool_reads / Uptime
Meaning: Reads
Recommended range: 0-100/sec.
What to do if out of range: Increase innodb_buffer_pool_size?

Expression: (Innodb_buffer_pool_reads + Innodb_buffer_pool_pages_flushed)  / Uptime
Meaning: InnoDB I/O
Recommended range: 0-100/sec.
What to do if out of range: Increase innodb_buffer_pool_size?

Expression: Innodb_buffer_pool_pages_flushed / Uptime
Meaning: Writes (flushes)
Recommended range: 0-100/sec.
What to do if out of range: Increase innodb_buffer_pool_size?

Expression: Innodb_buffer_pool_wait_free / Uptime
Meaning: Counter for when there are no free pages in buffer_pool. That is, all pages are dirty.
Recommended range: 0-1/sec.
What to do if out of range: First be sure innodb_buffer_pool_size is set reasonably; if still trouble, decrease innodb_max_dirty_pages_pct